About Parkinson's Disease
The diagnosis of Parkinson's disease can cause fear, anxiety, anger, and disappointment for the individual and the entire family. Often times, the diagnosis is accompanied by little or no information about the disease, prognosis, or its management. Click on the links below for additional information on Parkinson's disease.
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. There are between 1 and 1.5 million Americans living with Parkinson's disease. Although there is a wide variation in the way the disease presents between individuals, the four cardinal motor symptoms are:
- Tremor (shaking)
- Slowness of movement
- Rigidity (stiffness)
- Difficulty with balance
When at least two of these symptoms are present, and especially if they are more evident on one side than the other, a diagnosis of PD is made, unless there are atypical features that suggest an alternative diagnosis. Patients may first realize something is wrong when they develop a tremor in a limb; movements are slowed and activities take longer to perform; or they experience stiffness and have balance problems. Initially, symptoms are a variable combination of tremor, bradykinesia, rigidity, and postural instability. Symptoms typically begin on one side of the body and spread over time to the other side.
Other signs of Parkinson's disease may include:
- Small, cramped handwriting
- Stiff facial expression
- Shuffling walk
- Muffled speech
Changes occur in facial expression, so that there is a certain facial fixity (blank expression showing little emotion) or a staring appearance (due to reduced frequency of eye blinking). Complaints of a frozen shoulder or foot drag on the affected side are not uncommon. As symptoms come on gradually, older patients may attribute these changes to aging. The tremor is thought to be “shakiness,” bradykinesia is regarded as normal “slowing down,” and stiffness is attributed to arthritis. The stooped posture, common to PD, may be attributed to age or osteoporosis. Both younger and older patients may experience initial symptoms for a year or more before seeking medical evaluation.
A recent study published in the January 15, 2010 issue of Neuroepidemiology1 reported some previously unknown information on the incidence2 and prevalence3 of Parkinson's disease in the United States. Allison Wright Willis, MD and others at the Washington University School of Medicine discovered in the largest epidemiological study of Parkinson's disease in the United States that the disease is more common in the Midwest and the Northeast and is twice as likely to occur in whites and Hispanics as it is in blacks and Asians. Other interesting findings were:
- PD affects approximately 1.6% of the American population over the age of 65
- Approximately 60,000 people are newly diagnosed in the U.S. each year
- Men are more likely to have the disease than women (1.55:1.0)
- Asian women seem to have the lowest incidence rates in the U.S.
- Prevalence and annual incidence of PD appears to increase with age without plateau (as previously suspected in some reports)
If you or your loved ones need information on PD, our staff can help you or refer you to someone who can answer your question.
The foundation is located at 575 Lincoln Avenue, in Pittsburgh's North Hills (15202). Our phone number is 412.837.2542.
 Wright Willis A, Evanoff BA, Lian M, Criswell SR, Racette BA. Geographic and ethnic variation in Parkinson's disease: a population-based study of US Medicare beneficiaries. Neuroepidemiology, 2010;34:143-151
 Incidence is the number of new cases per population in a given time period
 Prevalence is the total number of cases of a Parkinson's disease present in a given population at a given time.
Incidence conveys information about the risk of contracting the disease, whereas prevalence indicates how widespread the disease is. For example, consider a disease that takes a long time to cure, and that was spread widely in 2002, but whose spread was arrested in 2003. This disease will have a high prevalence and a high incidence in 2002; but in 2003 it will have a low incidence, although it will continue to have a high prevalence because the number of affected individuals remains high. In contrast, a disease that has a short duration may have a low prevalence and a high incidence.
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