Anticholinergics: Anticholinergics do not act directly on the dopaminergic system. Instead, they decrease the activity of acetylcholine, a neurotransmitter that regulates movement and memory.
Amantadine (Symmetrel™) promotes the release of dopamine from nerve terminals, blocks its re-uptake and inhibits a glutamate receptor in the brain. It may decrease the activity of acetylcholine, which regulates movement and memory.
Droxidopa (Northera™) is a synthetic precursor of norepinephrine, which works to increase blood pressure in a condition that can accompany Parkinson’s disease called neurogenic orthostatic hypotension (NOH). This condition can cause an abnormal drop in blood pressure when changing positions.
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